These secretagogues are longer-acting; workload is increased on the pancreas for a longer period and can cause beta cell burnout. Also available in combination products.

Product Name
Amaryl® (glimepiride)
DiaBeta® (glyburide USP)
DIABINESE® (chlorpropamide) tablets, USP
GLUCOTROL XL® (glipizide) extended release tablets
GLUCOTROL® (glipizide) tablets
Micronase® (glyburide) tablets, USP